Osteoarthritis or degenerative joint disease (DJD) leads to joint destruction and cartilage damage which can lead to pain and dissability. Non steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, Motrin and Advil are commonly used to treat DJD, However, these agents have potential serious gastrointestinal side effects such as ulcers and bleeding. Glucosamine has been used in Europe for almost 40 years without any demonstrated side effects. Recent studies in the United States have also proven Glucosamine to be beneficial in this disease for pain relief.